منابع مشابه
the tragedy of modern man in arthur millers world
what miller wants is a theatre of heightened consciousness. he speaks of two passions in a man, the passion to "feel" and the passion "know". he belives that we can have more of the latter. he says: drama is akin to the other inventions of man in that it ought to help us know more and not merely to spend our feelings. the writing of the crucible shows us that he is trying to give more heightene...
15 صفحه اولMetabolism of 14C-labelled alphaxalone in man.
The metabolism of 14C-labelled alphaxalone, dispensed as Althesin, was studied in normal patients, patients with obstructive jaundice and patients with chronic renal disease and anuria. The radioactive label was removed rapidly from the plasma following i.v. administration. The major portion of the label was excreted in the urine. In patients with normal renal function 14C-labelled alphaxalone ...
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1. The fate of [(14)C]thalidomide orally administered to pregnant rabbits at the beginning of the sensitive phase of pregnancy has been studied. 2. After the oral administration of [(14)C]thalidomide on the 192nd hour of pregnancy about 68% of the radioactivity appears in the urine and 22% in the faeces. 3. The urinary (14)C is made up as follows (% of dose): thalidomide (2); alpha-(o-carboxybe...
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metabolites were isolated by ion exchange methods, identified by gas chromatography-mass spectrometry, and quantitated using thin-layer chromatography with a radiochromatogram scanner. The urinary metabolites of HMM in both rats and man were A^-demethylated homologs of HMM. These experi ments suggest that in man and rats there is no significant metabolic cleavage of the s-triazine ring and that...
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Therapeutic agents, in general, undergo chemical alteration in the body to form derivatives of the parent compound. Isolation and pharmacological assay of the various transformation products may yield valuable information in the Senrch for better therapeutic agents, in studies on the mechanism of drug action :,*d in the elucidation of norm+l metabolic processes. The therapeutic effect of a drug...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1977
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1977.tb00664.x